The influence of psychological stress on the immune response to vaccines.
Identifieur interne : 002F56 ( Main/Exploration ); précédent : 002F55; suivant : 002F57The influence of psychological stress on the immune response to vaccines.
Auteurs : R. Glaser [États-Unis] ; J K Kiecolt-Glaser ; W B Malarkey ; J F SheridanSource :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 1998.
Descripteurs français
- KwdFr :
- Aidants (psychologie), Anticorps antiviraux (analyse), Humains, Interleukine-2 (biosynthèse), Lymphocytes T (métabolisme), Maladie d'Alzheimer (), Orthomyxoviridae (immunologie), Production d'anticorps (), Stress psychologique (immunologie), Stress psychologique (physiopathologie), Sujet âgé, Système immunitaire (), Vaccins antiviraux (usage thérapeutique), Virus de l'hépatite B (immunologie), Études longitudinales.
- MESH :
- analyse : Anticorps antiviraux.
- biosynthèse : Interleukine-2.
- immunologie : Orthomyxoviridae, Stress psychologique, Virus de l'hépatite B.
- métabolisme : Lymphocytes T.
- physiopathologie : Stress psychologique.
- psychologie : Aidants.
- usage thérapeutique : Vaccins antiviraux.
- Humains, Maladie d'Alzheimer, Production d'anticorps, Sujet âgé, Système immunitaire, Études longitudinales.
English descriptors
- KwdEn :
- Aged, Alzheimer Disease (therapy), Antibodies, Viral (analysis), Antibody Formation (drug effects), Caregivers (psychology), Hepatitis B virus (immunology), Humans, Immune System (drug effects), Interleukin-2 (biosynthesis), Longitudinal Studies, Orthomyxoviridae (immunology), Stress, Psychological (immunology), Stress, Psychological (physiopathology), T-Lymphocytes (metabolism), Viral Vaccines (therapeutic use).
- MESH :
- chemical , analysis : Antibodies, Viral.
- chemical , biosynthesis : Interleukin-2.
- drug effects : Antibody Formation, Immune System.
- immunology : Hepatitis B virus, Orthomyxoviridae, Stress, Psychological.
- metabolism : T-Lymphocytes.
- physiopathology : Stress, Psychological.
- psychology : Caregivers.
- chemical , therapeutic use : Viral Vaccines.
- therapy : Alzheimer Disease.
- Aged, Humans, Longitudinal Studies.
Abstract
We compared virus-specific antibody and T-cell responses to influenza virus vaccination in 32 caregivers of Alzheimer's disease (AD) patients and matched control subjects. Caregivers showed a poorer antibody response and virus-specific T-cell response following vaccination compared to the control subjects as measured by fourfold increases in antibody titers to the vaccine and lower levels of virus-induced IL-2 levels in vitro. We performed a second study in which forty-eight medical students were inoculated with a series of three injections of the hepatitis-B (HEP-B) vaccine to coincide with the third day of three, three-day examination blocks. Twelve of the 48 medical students seroconverted after the first injection; these students were characterized by falling into the lower stressed/lower anxiety group of students. Students who reported greater social support and lower anxiety and stress demonstrated a higher antibody response to the vaccine and a more vigorous T-cell response to HEP-B surface antigen at the end of the third examination experience. The differences in antibody and T-cell responses to HEP-B and influenza virus vaccinations provide a demonstration of how stress may be able to alter both the cellular and humoral immune responses to vaccines and novel pathogens in both younger and older adults.
DOI: 10.1111/j.1749-6632.1998.tb09603.x
PubMed: 9629291
Affiliations:
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Le document en format XML
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Glaser</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Microbiology, Ohio State University College of Medicine, Columbus 43210, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Microbiology, Ohio State University College of Medicine, Columbus 43210</wicri:regionArea><wicri:noRegion>Columbus 43210</wicri:noRegion></affiliation></author><author><name sortKey="Kiecolt Glaser, J K" sort="Kiecolt Glaser, J K" uniqKey="Kiecolt Glaser J" first="J K" last="Kiecolt-Glaser">J K Kiecolt-Glaser</name></author><author><name sortKey="Malarkey, W B" sort="Malarkey, W B" uniqKey="Malarkey W" first="W B" last="Malarkey">W B Malarkey</name></author><author><name sortKey="Sheridan, J F" sort="Sheridan, J F" uniqKey="Sheridan J" first="J F" last="Sheridan">J F Sheridan</name></author></analytic><series><title level="j">Annals of the New York Academy of Sciences</title><idno type="ISSN">0077-8923</idno><imprint><date when="1998" type="published">1998</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Alzheimer Disease (therapy)</term><term>Antibodies, Viral (analysis)</term><term>Antibody Formation (drug effects)</term><term>Caregivers (psychology)</term><term>Hepatitis B virus (immunology)</term><term>Humans</term><term>Immune System (drug effects)</term><term>Interleukin-2 (biosynthesis)</term><term>Longitudinal Studies</term><term>Orthomyxoviridae (immunology)</term><term>Stress, Psychological (immunology)</term><term>Stress, Psychological (physiopathology)</term><term>T-Lymphocytes (metabolism)</term><term>Viral Vaccines (therapeutic use)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Aidants (psychologie)</term><term>Anticorps antiviraux (analyse)</term><term>Humains</term><term>Interleukine-2 (biosynthèse)</term><term>Lymphocytes T (métabolisme)</term><term>Maladie d'Alzheimer ()</term><term>Orthomyxoviridae (immunologie)</term><term>Production d'anticorps ()</term><term>Stress psychologique (immunologie)</term><term>Stress psychologique (physiopathologie)</term><term>Sujet âgé</term><term>Système immunitaire ()</term><term>Vaccins antiviraux (usage thérapeutique)</term><term>Virus de l'hépatite B (immunologie)</term><term>Études longitudinales</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Interleukin-2</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Interleukine-2</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Antibody Formation</term><term>Immune System</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Orthomyxoviridae</term><term>Stress psychologique</term><term>Virus de l'hépatite B</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Hepatitis B virus</term><term>Orthomyxoviridae</term><term>Stress, Psychological</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Lymphocytes T</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Stress psychologique</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Stress, Psychological</term></keywords><keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Aidants</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Caregivers</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Alzheimer Disease</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Vaccins antiviraux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Humans</term><term>Longitudinal Studies</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Maladie d'Alzheimer</term><term>Production d'anticorps</term><term>Sujet âgé</term><term>Système immunitaire</term><term>Études longitudinales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We compared virus-specific antibody and T-cell responses to influenza virus vaccination in 32 caregivers of Alzheimer's disease (AD) patients and matched control subjects. Caregivers showed a poorer antibody response and virus-specific T-cell response following vaccination compared to the control subjects as measured by fourfold increases in antibody titers to the vaccine and lower levels of virus-induced IL-2 levels in vitro. We performed a second study in which forty-eight medical students were inoculated with a series of three injections of the hepatitis-B (HEP-B) vaccine to coincide with the third day of three, three-day examination blocks. Twelve of the 48 medical students seroconverted after the first injection; these students were characterized by falling into the lower stressed/lower anxiety group of students. Students who reported greater social support and lower anxiety and stress demonstrated a higher antibody response to the vaccine and a more vigorous T-cell response to HEP-B surface antigen at the end of the third examination experience. The differences in antibody and T-cell responses to HEP-B and influenza virus vaccinations provide a demonstration of how stress may be able to alter both the cellular and humoral immune responses to vaccines and novel pathogens in both younger and older adults.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Kiecolt Glaser, J K" sort="Kiecolt Glaser, J K" uniqKey="Kiecolt Glaser J" first="J K" last="Kiecolt-Glaser">J K Kiecolt-Glaser</name><name sortKey="Malarkey, W B" sort="Malarkey, W B" uniqKey="Malarkey W" first="W B" last="Malarkey">W B Malarkey</name><name sortKey="Sheridan, J F" sort="Sheridan, J F" uniqKey="Sheridan J" first="J F" last="Sheridan">J F Sheridan</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Glaser, R" sort="Glaser, R" uniqKey="Glaser R" first="R" last="Glaser">R. Glaser</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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